Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes
نویسندگان
چکیده
منابع مشابه
Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes
MicroRNA (miRNA)-guided argonaute (Ago) controls gene expression upon binding to the 3' UTR of mRNA. The miRNA function can be competitively inhibited by single-stranded anti-miRNA oligonucleotides (AMOs). In this study, we constructed a novel type of AMO flanked by interstrand cross-linked 2'-O-methylated RNA duplexes (CLs) that confer a stable helical conformation. Compared with other structu...
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ژورنال
عنوان ژورنال: Molecular Therapy - Nucleic Acids
سال: 2018
ISSN: 2162-2531
DOI: 10.1016/j.omtn.2017.11.003